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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Q Shi, C Xue, Y Zeng, X Yuan, Q Chu, S Jiang… - … and Targeted Therapy, 2024 - nature.com
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
Exploiting innate immunity for cancer immunotherapy
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance
Prostate cancer is characterized by a high degree of heterogeneity, which poses a major
challenge to precision therapy and drug development. In this review, we discuss how …
challenge to precision therapy and drug development. In this review, we discuss how …
Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer
Cancer involves cells' abnormal growth and ability to invade or metastasize to different body
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …
Radiomics in prostate cancer: An up-to-date review
Prostate cancer (PCa) is the most common worldwide diagnosed malignancy in male
population. The diagnosis, the identification of aggressive disease, and the post-treatment …
population. The diagnosis, the identification of aggressive disease, and the post-treatment …
Using PSMA imaging for prognostication in localized and advanced prostate cancer
The use of prostate-specific membrane antigen (PSMA)-directed applications in modern
prostate cancer management has evolved rapidly over the past few years, hel** to …
prostate cancer management has evolved rapidly over the past few years, hel** to …
Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer
When compared to other malignancies, the tumor microenvironment (TME) of primary and
castration-resistant prostate cancer (CRPC) is relatively devoid of immune infiltrates. While …
castration-resistant prostate cancer (CRPC) is relatively devoid of immune infiltrates. While …
Nanotechnological approaches in prostate cancer therapy: integration of engineering and biology
Nanocarriers have received special attention in biomedicine for the treatment of various
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
Phenotype switching and the melanoma microenvironment; impact on immunotherapy and drug resistance
Melanoma, a highly heterogeneous tumor, is comprised of a functionally diverse spectrum of
cell phenotypes and subpopulations, including stromal cells in the tumor microenvironment …
cell phenotypes and subpopulations, including stromal cells in the tumor microenvironment …
Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics
requires quantitative measurements in controlled clinical trials. We mapped genomic …
requires quantitative measurements in controlled clinical trials. We mapped genomic …