The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …

Despite remarkable successes in the clinic, cancer targeted therapy development remains
challenging and the failure rate is disappointingly high. This problem is partly due to the …

Background Alisertib is an investigational, oral, selective inhibitor of aurora kinase A. We
aimed to investigate the safety and activity of single-agent alisertib in patients with …

Aurora kinase belongs to serine/threonine kinase family which controls cell division.
Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

Abstract Purpose: Human papillomavirus (HPV)-negative head and neck squamous cell
carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers …

Unraveling the underlying mechanisms of cetuximab resistance in head and neck
squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non …

Purpose: Effective therapy for recurrent head and neck squamous cell carcinoma (HNSCC)
that is refractory to chemotherapy and immunotherapy is a considerable need. Aurora …

Chromatin remodeling proteins contribute to DNA replication, transcription, repair, and
recombination. The chromodomain helicase DNA-binding (CHD) family of remodelers plays …