[HTML][HTML] Cysteine cathepsins: from structure, function and regulation to new frontiers
It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …
machinery, including proteases and other hydrolases, has been fairly well identified and …
[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential
P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …
particular interest due to distinctive properties including a normal restricted expression …
[HTML][HTML] Lysosomal cathepsins and their regulation in aging and neurodegeneration
Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …
change their properties with aging brain a long time ago, although their function was not …
Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S
ML Biniossek, DK Nägler… - Journal of proteome …, 2011 - ACS Publications
Cysteine cathepsins mediate proteome homeostasis and have pivotal functions in diseases
such as cancer. To better understand substrate recognition by cathepsins B, L, and S, we …
such as cancer. To better understand substrate recognition by cathepsins B, L, and S, we …
Comprehensive search for cysteine cathepsins in the human genome
Our study was aimed at examinating whether or not the human genome encodes for
previously unreported cysteine cathepsins. To this end, we used analyses of the genome …
previously unreported cysteine cathepsins. To this end, we used analyses of the genome …
TRPV4 as a therapeutic target for joint diseases
Biomechanical factors play a critical role in regulating the physiology as well as the
pathology of multiple joint tissues and have been implicated in the pathogenesis of …
pathology of multiple joint tissues and have been implicated in the pathogenesis of …
Lysosomal cysteine proteases (cathepsins): promising drug targets
Papain-like lysosomal cysteine proteases are processive and digestive enzymes expressed
in organisms from bacteria to humans. Their ubiquity alone makes them potential drug …
in organisms from bacteria to humans. Their ubiquity alone makes them potential drug …
Plasmodium falciparum SERA5 plays a non‐enzymatic role in the malarial asexual blood‐stage lifecycle
R Stallmach, M Kavishwar… - Molecular …, 2015 - Wiley Online Library
The malaria parasite P lasmodium falciparum replicates in an intraerythrocytic
parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA 5 …
parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA 5 …
Development of nitrile-based peptidic inhibitors of cysteine cathepsins
M Frizler, M Stirnberg, MT Sisay… - Current topics in …, 2010 - ingentaconnect.com
It is now becoming clear that several papain-like cysteine cathepsins are involved in the
pathophysiology of diseases such as osteoporosis, autoimmune disorders, and cancer …
pathophysiology of diseases such as osteoporosis, autoimmune disorders, and cancer …
Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation
Cysteine cathepsins play an indispensable role in proteolytic processing of the major
histocompatibility complex class II-associated invariant chain (Ii) and foreign antigens in a …
histocompatibility complex class II-associated invariant chain (Ii) and foreign antigens in a …