Neuroplasticity underlying the comorbidity of pain and depression
L Doan, T Manders, J Wang - Neural plasticity, 2015 - Wiley Online Library
Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …
Depression, meanwhile, can also adversely affect pain behaviors ranging from …
Cell type-specific dissection of sensory pathways involved in descending modulation
Decades of research have suggested that stimulation of supraspinal structures, such as the
periaqueductal gray (PAG) and rostral ventromedial medulla (RVM), inhibits nocifensive …
periaqueductal gray (PAG) and rostral ventromedial medulla (RVM), inhibits nocifensive …
Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain
modulatory system and is a crucial site for opioid-induced analgesia. A number of previous …
modulatory system and is a crucial site for opioid-induced analgesia. A number of previous …
(2R, 6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray
D Chou, HY Peng, TB Lin, CY Lai, MC Hsieh… - …, 2018 - Elsevier
It has been widely reported that ketamine rescues chronic stress-induced depression-like
behavior, but the underlying cellular mechanisms of the rapid antidepressant actions of …
behavior, but the underlying cellular mechanisms of the rapid antidepressant actions of …
Reversible induction of pain hypersensitivity following optogenetic stimulation of spinal astrocytes
While glial activation is an integral part of pain pathogenesis, the existence of a causal
relationship between glia and pain processing has yet to be demonstrated in vivo. Here, we …
relationship between glia and pain processing has yet to be demonstrated in vivo. Here, we …
Brainstem pain-modulation circuitry and its plasticity in neuropathic pain: insights from human brain imaging investigations
Acute pain serves as a protective mechanism that alerts us to potential tissue damage and
drives a behavioural response that removes us from danger. The neural circuitry critical for …
drives a behavioural response that removes us from danger. The neural circuitry critical for …
High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain
K Hisaoka-Nakashima, K Ohata, N Yoshimoto… - Experimental …, 2022 - Elsevier
Clinical evidence indicates that cognitive impairment is a common comorbidity of chronic
pain, including neuropathic pain, but the mechanism underlying cognitive impairment …
pain, including neuropathic pain, but the mechanism underlying cognitive impairment …
Neurobiology of depression: chronic stress alters the glutamatergic system in the brain—focusing on AMPA receptor
Major depressive disorder (MDD) is a common neuropsychiatric disorder affecting the mood
and mental well-being. Its pathophysiology remains elusive due to the complexity and …
and mental well-being. Its pathophysiology remains elusive due to the complexity and …
Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?
Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …
Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction in rats with neuropathic pain
B **ong, W Zhang, L Zhang, X Huang, W Zhou, Q Zou… - Pain, 2020 - journals.lww.com
Cognitive impairment is one of the most common complications associated with chronic
pain. Almost 20% of chronic pain patients suffer from cognitive impairment, which may …
pain. Almost 20% of chronic pain patients suffer from cognitive impairment, which may …