Organoids, miniature and simplified in vitro model systems that mimic the structure and
function of organs, have attracted considerable interest due to their promising applications in …

Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are
important preclinical models for studying cancer and develo** therapies. Here, we review …

Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma,
leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia …

Organoids are a new type of 3D model for tumor research, which makes up for the
shortcomings of cell lines and xenograft models, and promotes the development of …

In recent years, the classification of adult-type diffuse gliomas has undergone a revolution,
wherein specific molecular features now represent defining diagnostic criteria of IDH-wild …

Brain tumors are the leading cause of cancer‐related death in children. Experimental in vitro
models that faithfully capture the hallmarks and tumor heterogeneity of pediatric brain …

Isocitrate dehydrogenase (IDH) mutants define a class of gliomas that are initially slow-
growing but inevitably progress to fatal disease. To characterize their malignant cell …

Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …

Organoids present substantial potential for pushing forward preclinical research and
personalized medicine by accurately recapitulating tissue and tumor heterogeneity in vitro …

Rhabdomyosarcomas (RMS) are mesenchyme‐derived tumors and the most common
childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for …