Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …

To protect tissues and the organism from disease, potentially harmful cells are removed
through programmed cell death processes, including apoptosis and necroptosis. These …

Non-small-cell lung cancer is often diagnosed at the metastatic stage, with median survival
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …

Toll-like receptors (TLRs) in innate immune cells are the prime cellular sensors for microbial
components. TLR activation leads to the production of proinflammatory mediators and thus …

During the last two decades, microRNAs (miRNAs) emerged as critical regulators of gene
expression. By modulating the expression of numerous target mRNAs mainly at the post …

Recent research has demonstrated that microRNAs (miRNAs) are key regulators of many
cell processes often deregulated in cancer, including apoptosis. Indeed, it is becoming clear …

Non-small cell lung cancer (NSCLC) accounts for∼ 80% of all lung cancers. Although some
advances in lung cancer therapy have been made, patient survival is still quite poor. Two …

Drug resistance remains a major problem in the treatment of cancer patients for both
conventional chemotherapeutic and novel biological agents. Intrinsic or acquired resistance …

Glioblastoma is the most frequent brain tumor in adults and is the most lethal form of human
cancer. Despite the improvements in treatments, survival of patients remains poor. In order …

Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however
the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report …