Recent advances in indazole-containing derivatives: synthesis and biological perspectives
SG Zhang, CG Liang, WH Zhang - Molecules, 2018 - mdpi.com
Indazole-containing derivatives represent one of the most important heterocycles in drug
molecules. Diversely substituted indazole derivatives bear a variety of functional groups and …
molecules. Diversely substituted indazole derivatives bear a variety of functional groups and …
Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity
K D'Ambrosio, A Di Fiore, V Alterio, E Langella… - Chemical …, 2024 - ACS Publications
Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the
hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of …
hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of …
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies
Carbonic anhydrases isoforms CA IX, and XII are known to be highly expressed in various
human tissues and malignancies. CA IX is a prominent target for especially colorectal …
human tissues and malignancies. CA IX is a prominent target for especially colorectal …
Carbonic anhydrases: Versatile and useful biocatalysts in chemistry and biochemistry
Metalloenzymes such as the carbonic anhydrases (CAs, EC 4.2. 1.1) possess highly
specialized active sites that promote fast reaction rates and high substrate selectivity for the …
specialized active sites that promote fast reaction rates and high substrate selectivity for the …
Develo** hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery
Hybrid drugs featuring two or more potentially bioactive pharmacophores have been
recognized as advanced and superior chemical entities to simultaneously modulate multiple …
recognized as advanced and superior chemical entities to simultaneously modulate multiple …
pH regulators and their inhibitors in tumor microenvironment
S Liao, G Wu, Z **e, X Lei, X Yang, S Huang… - European journal of …, 2024 - Elsevier
As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely
related to immune escape, invasion, migration and drug resistance of tumor. The acidity of …
related to immune escape, invasion, migration and drug resistance of tumor. The acidity of …
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective …
A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the
alkyl chains was synthesized and their inhibitory activity against the human carbonic …
alkyl chains was synthesized and their inhibitory activity against the human carbonic …
Tail-approach-based design and synthesis of coumarin-monoterpenes as carbonic anhydrase inhibitors and anticancer agents
In this study, sixty novel coumarin-monoterpene compounds were synthesized in two series
[thirty-two compounds (12–43) bearing a triazole ring in the first series, and twenty-eight …
[thirty-two compounds (12–43) bearing a triazole ring in the first series, and twenty-eight …
Synthesis and biological evaluation of coumarin-1, 3, 4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors
With an aim to develop novel heterocyclic hybrids as potent anticancer agents, we
synthesized a series of coumarin-1, 3, 4-oxadiazole hybrids (7a-t) and evaluated for their …
synthesized a series of coumarin-1, 3, 4-oxadiazole hybrids (7a-t) and evaluated for their …
Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII
A series of 6-ureido/amidocoumarins (5a–p and 7a–c) has been designed and synthesised
to develop potent and isoform-selective carbonic anhydrase h CA XI and XII inhibitors. All …
to develop potent and isoform-selective carbonic anhydrase h CA XI and XII inhibitors. All …