Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery

AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self‐emulsifying systems

S Gupta, R Kesarla, A Omri - International Scholarly Research …, 2013 - Wiley Online Library
Poorly water‐soluble drug candidates are becoming more prevalent. It has been estimated
that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous …

Lipid based nanocarriers: a translational perspective

DK Mishra, R Shandilya, PK Mishra - … : Nanotechnology, Biology and …, 2018 - Elsevier
Over the recent couple of decades, pharmaceutical field has embarked most phenomenal
noteworthy achievements in the field of medications as well as drug delivery. The rise of …

Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis

MB Zewail, SA El-Gizawy, GF Asaad… - International Journal of …, 2023 - Elsevier
Rheumatoid arthritis (RA), a distressing inflammatory autoimmune disease, is managed
mainly by Disease-modifying antirheumatic drugs (DMARDs), eg leflunomide (LEF). LEF …

Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization, in vitro and in vivo …

AW Khan, S Kotta, SH Ansari, RK Sharma, J Ali - Drug delivery, 2015 - Taylor & Francis
Naringenin (NRG), predominant flavanone in grapefruits, possesses anti-inflammatory, anti-
carcinogenic, hepato-protective and anti-lipid peroxidation effects. Slow dissolution after oral …

Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation

K Balakumar, CV Raghavan, S Abdu - Colloids and Surfaces B …, 2013 - Elsevier
The aim of the present study is to improve solubility and bioavailability of Rosuvastatin
calcium using self nanoemulsifying drug delivery system (SNEDDS). Self emulsifying …

Freeze-drying: A flourishing strategy to fabricate stable pharmaceutical and biological products

KK Abla, MM Mehanna - International journal of pharmaceutics, 2022 - Elsevier
Freeze-drying (FD) of nanoparticles, microorganisms, genes, and vaccines is an auspicious
technique used to enhance long-term stability and facilitate transportation mainly for …

Self-nanoemulsifying drug delivery system (SNEDDS) for improved oral bioavailability of chlorpromazine: in vitro and in vivo evaluation

J Baloch, MF Sohail, HS Sarwar, MH Kiani, GM Khan… - Medicina, 2019 - mdpi.com
Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems
(SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer …

Freeze-drying of emulsified systems: A review

AR do Vale Morais, É do Nascimento Alencar… - International journal of …, 2016 - Elsevier
Colloidal systems such as emulsions, microemulsions and nanoemulsions are able to
transport active molecules, enhance their solubility and stability and minimize their side …

Systematic approach for the formulation and optimization of solid lipid nanoparticles of efavirenz by high pressure homogenization using design of experiments for …

S Gupta, R Kesarla, N Chotai, A Misra… - Biomed research …, 2017 - Wiley Online Library
The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections,
are reported to have low bioavailability pertaining to high first‐pass metabolism, high protein …