A platform for experimental precision medicine: The extended BXD mouse family
The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …
phenotypes, development, environments, and treatments. We address this challenge by …
NMNAT2 is a druggable target to drive neuronal NAD production
Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD
pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical …
pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical …
Highlights from the era of open source web-based tools
High digital connectivity and a focus on reproducibility are contributing to an open science
revolution in neuroscience. Repositories and platforms have emerged across the whole …
revolution in neuroscience. Repositories and platforms have emerged across the whole …
The cocaine and oxycodone biobanks, two repositories from genetically diverse and behaviorally characterized rats for the study of addiction
The rat oxycodone and cocaine biobanks contain samples that vary by genotypes (by using
genetically diverse genotyped HS rats), phenotypes (by measuring addiction-like behaviors …
genetically diverse genotyped HS rats), phenotypes (by measuring addiction-like behaviors …
The expanded BXD family of mice: a cohort for experimental systems genetics and precision medicine
The challenge of precision medicine is to model complex interactions among DNA variants,
sets of phenotypes, and complex environmental factors and confounders. We have …
sets of phenotypes, and complex environmental factors and confounders. We have …
Private and sub-family specific mutations of founder haplotypes in the BXD family reveal phenotypic consequences relevant to health and disease
The BXD recombinant inbred (RI) mouse strains are the largest and most deeply
phenotyped inbred panel of vertebrate organisms. RIs allow phenoty** of isogenic …
phenotyped inbred panel of vertebrate organisms. RIs allow phenoty** of isogenic …
Born to cry: A genetic dissection of infant vocalization
Infant vocalizations are one of the most fundamental and innate forms of behavior
throughout avian and mammalian orders. They have a critical role in motivating parental …
throughout avian and mammalian orders. They have a critical role in motivating parental …
Genome-wide transcriptome architecture in a mouse model of Gulf War Illness
Abstract Gulf War Illness (GWI) is thought to be a chronic neuroimmune disorder caused by
in-theater exposure during the 1990–1991 Gulf War. There is a consensus that the illness is …
in-theater exposure during the 1990–1991 Gulf War. There is a consensus that the illness is …
The influence of hypoxia on the prostate cancer proteome
Prostate cancer accounts for around 15% of male deaths in Western Europe and is the
second leading cause of cancer death in men after lung cancer. Mounting evidence …
second leading cause of cancer death in men after lung cancer. Mounting evidence …
Genetic contribution to initial and progressive alcohol intake among recombinant inbred strains of mice
We profiled individual differences in alcohol consumption upon initial exposure and during 5
weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains …
weeks of voluntary alcohol intake in female mice from 39 BXD recombinant inbred strains …