Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Bone-related maladies are a major health burden on modern society. Loss of skeletal
integrity and regeneration capacity through aging, obesity, and disease follows from a …

Loss of skeletal integrity during ageing and disease is associated with an imbalance in the
opposing actions of osteoblasts and osteoclasts. Here we show that intrinsic ageing of …

Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive
destruction of articular cartilage. The etiology of OA is complex and involves a variety of …

In lactating mothers, the high calcium (Ca2+) demand for milk production triggers significant
bone loss. Although oestrogen normally counteracts excessive bone resorption by …

Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …

Skeletal stem cells (SSCs) that are capable of self-renewal and multipotent differentiation
contribute to bone development and homeostasis. Several populations of SSCs at different …

Human skeletal stem cells (hSSCs) hold tremendous therapeutic potential for develo**
new clinical strategies to effectively combat congenital and age-related musculoskeletal …

Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones.
However, the spatiotemporal ontogeny of human embryonic SSCs during early …

Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a
number of systemic hormones and transcription factors are known to regulate proliferation …