Current treatment for venom-induced consumption coagulopathy resulting from snakebite

K Maduwage, GK Isbister - PLoS neglected tropical diseases, 2014 - journals.plos.org
Venomous snakebite is considered the single most important cause of human injury from
venomous animals worldwide. Coagulopathy is one of the commonest important systemic …

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

DJ Williams, JM Gutiérrez, JJ Calvete, W Wüster… - Journal of …, 2011 - Elsevier
The development of snake antivenoms more than a century ago should have heralded
effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural …

Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia

KY Tan, CH Tan, SY Fung, NH Tan - Journal of proteomics, 2015 - Elsevier
Previous studies showed that venoms of the monocled cobra, Naja kaouthia from Thailand
and Malaysia are substantially different in their median lethal doses. The intraspecific venom …

[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by …

D Petras, L Sanz, A Segura, M Herrera… - Journal of proteome …, 2011 - ACS Publications
Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica,
and N. pallida revealed similar compositional trends. The high content of cytotoxins and …

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

JM Gutiérrez, B Lomonte, G León, A Alape-Giron… - Journal of …, 2009 - Elsevier
Snakebite envenoming represents a neglected tropical disease that has a heavy public
health impact, particularly in Asia, Africa and Latin America. A global initiative, aimed at …

New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India

DA Warrell, JM Gutiérrez, JJ Calvete… - Indian Journal of …, 2013 - journals.lww.com
The direct estimate of 46,000 snakebite deaths in India in 2005 (1 for every 2 HIV/AIDS
deaths), based on verbal autopsies, renders unrealistic the total of only 47,000 snakebite …

Immune response towards snake venoms

G León, L Sánchez, A Hernández… - … & Allergy-Drug …, 2011 - ingentaconnect.com
The immune response involves a complex repertoire of innate and adaptive responses to
foreign agents in the organism. The present review focuses on the immune response to …

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of …

S Ainsworth, D Petras, M Engmark, RD Süssmuth… - Journal of …, 2018 - Elsevier
Mambas (genus Dendroaspis) are among the most feared of the medically important elapid
snakes found in sub-Saharan Africa, but many facets of their biology, including the diversity …

Public health aspects of snakebite care in West Africa: perspectives from Nigeria

AG Habib - Journal of venomous animals and toxins including …, 2013 - SciELO Brasil
Snakebite envenoming is a major public health problem among rural communities of the
Nigerian savanna. The saw-scaled or carpet viper (Echis ocellatus) and, to a lesser extent …