[HTML][HTML] The human antibody response to influenza A virus infection and vaccination
The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …
involving antibody and cellular responses at both systemic and mucosal levels. Immune …
Advances in the development of influenza virus vaccines
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …
An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults
Influenza vaccines could be improved by platforms inducing cross-reactive immunity.
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans
Current yearly seasonal influenza vaccines primarily induce an antibody response directed
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
Immune history profoundly affects broadly protective B cell responses to influenza
SF Andrews, Y Huang, K Kaur, LI Popova… - Science translational …, 2015 - science.org
Generating a broadly protective influenza vaccine is critical to global health. Understanding
how immune memory influences influenza immunity is central to this goal. We undertook an …
how immune memory influences influenza immunity is central to this goal. We undertook an …
From original antigenic sin to the universal influenza virus vaccine
Antibody responses are essential for protection against influenza virus infection. Humans
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …
Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination
Antigen-specific B cells bifurcate into antibody-secreting cells (ASCs) and memory B cells
(MBCs) after infection or vaccination. ASCs (plasmablasts) have been extensively studied in …
(MBCs) after infection or vaccination. ASCs (plasmablasts) have been extensively studied in …
[HTML][HTML] Neutralization of SARS-CoV-2 by destruction of the prefusion spike
There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
Influenza virus hemagglutinin stalk-based antibodies and vaccines
Highlights•Hemagglutinin stalk-reactive monoclonal antibodies are able to neutralize
divergent influenza virus strains.•Stalk-reactive antibodies are currently being tested in …
divergent influenza virus strains.•Stalk-reactive antibodies are currently being tested in …
The memory B cell response to influenza vaccination is impaired in older persons
Influenza infection imparts an age-related increase in mortality and morbidity. The most
effective countermeasure is vaccination; however, vaccines offer modest protection in older …
effective countermeasure is vaccination; however, vaccines offer modest protection in older …