Targeting RNA structures with small molecules

JL Childs-Disney, X Yang, QMR Gibaut… - Nature Reviews Drug …, 2022 - nature.com
RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

J Han, J Wang, X Yang, H Yu, R Zhou, HC Lu… - Molecular cancer, 2019 - Springer
Background METTL3 is known to be involved in all stages in the life cycle of RNA. It affects
the tumor formation by the regulation the m6A modification in the mRNAs of critical …

MicroRNAs and their regulatory roles in plant–environment interactions

X Song, Y Li, X Cao, Y Qi - Annual review of plant biology, 2019 - annualreviews.org
MicroRNAs (miRNAs) are 20–24 nucleotide noncoding RNAs abundant in plants and
animals. The biogenesis of plant miRNAs involves transcription of miRNA genes, processing …

Impact of polyploidy on plant tolerance to abiotic and biotic stresses

VE Tossi, LJ Martínez Tosar, LE Laino… - Frontiers in Plant …, 2022 - frontiersin.org
Polyploidy, defined as the coexistence of three or more complete sets of chromosomes in an
organism's cells, is considered as a pivotal moving force in the evolutionary history of …

Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies

P Rousselle, F Braye, G Dayan - Advanced Drug Delivery Reviews, 2019 - Elsevier
Cutaneous wound healing in adult mammals is a complex multi-step process involving
overlap** stages of blood clot formation, inflammation, re-epithelialization, granulation …

History, discovery, and classification of lncRNAs

J Jarroux, A Morillon, M Pinskaya - Long non coding RNA biology, 2017 - Springer
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …