Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R)
promotes the differentiation of myeloid progenitors into heterogeneous populations of …
promotes the differentiation of myeloid progenitors into heterogeneous populations of …
Blood monocytes: development, heterogeneity, and relationship with dendritic cells
C Auffray, MH Sieweke… - Annual review of …, 2009 - annualreviews.org
Monocytes are circulating blood leukocytes that play important roles in the inflammatory
response, which is essential for the innate response to pathogens. But inflammation and …
response, which is essential for the innate response to pathogens. But inflammation and …
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia
A Gottschlich, M Thomas, R Grünmeier, S Lesch… - Nature …, 2023 - nature.com
Chimeric antigen receptor T cells (CAR-T cells) have emerged as a powerful treatment
option for individuals with B cell malignancies but have yet to achieve success in treating …
option for individuals with B cell malignancies but have yet to achieve success in treating …
Single-cell transcriptional profiling reveals cellular diversity and intercommunication in the mouse heart
Characterization of the cardiac cellulome, the network of cells that form the heart, is essential
for understanding cardiac development and normal organ function and for formulating …
for understanding cardiac development and normal organ function and for formulating …
[HTML][HTML] C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from
embryonic precursors that seed the tissues prior to birth to generate a self-renewing …
embryonic precursors that seed the tissues prior to birth to generate a self-renewing …
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural
GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy …
GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy …
[HTML][HTML] Microglia modulate wiring of the embryonic forebrain
P Squarzoni, G Oller, G Hoeffel, L Pont-Lezica… - Cell reports, 2014 - cell.com
Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the
etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to …
etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to …
Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility
Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial
changes. It is tightly regulated by complex cellular interactions; however, our understanding …
changes. It is tightly regulated by complex cellular interactions; however, our understanding …
T cell–induced CSF1 promotes melanoma resistance to PD1 blockade
NJ Neubert, M Schmittnaegel, N Bordry… - Science translational …, 2018 - science.org
Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage
differentiation that sustains the protumorigenic functions of tumor-associated macrophages …
differentiation that sustains the protumorigenic functions of tumor-associated macrophages …
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia
Summary Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control
macrophage development, maintenance, and function. The development of both …
macrophage development, maintenance, and function. The development of both …