Targeting IL-6 trans-signalling: past, present and future prospects
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …
Interleukin-6: obstacles to targeting a complex cytokine in critical illness
Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …
ROS1-dependent cancers—biology, diagnostics and therapeutics
The proto-oncogene ROS1 encodes a receptor tyrosine kinase with an unknown
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …
physiological role in humans. Somatic chromosomal fusions involving ROS1 produce …
[HTML][HTML] Therapeutic interleukin-6 trans-signaling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease
Background & Aims A large unmet therapeutic need exists in inflammatory bowel disease
(IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a …
(IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a …
Interleukin-6: designing specific therapeutics for a complex cytokine
Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …
functions that include regulation of immune cell proliferation and differentiation …
Interleukin-6 family cytokines
S Rose-John - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
The interleukin (IL)-6 family cytokines is a group of cytokines consisting of IL-6, IL-11, ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM) …
Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia
Chimeric antigen receptor (CAR)–modified T cells with anti-CD19 specificity are a highly
effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia …
effective novel immune therapy for relapsed/refractory acute lymphoblastic leukemia …
IL-6 as a keystone cytokine in health and disease
CA Hunter, SA Jones - Nature immunology, 2015 - nature.com
Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …
of the immune system and often displays hormone-like characteristics that affect homeostatic …