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Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …
with a growing number of clinical studies examining a wide range of conditions and …
Expectancy effects in psychedelic trials
Clinical trials of psychedelic compounds like psilocybin, LSD and DMT have forced a
reconsideration of how non-drug factors, like participant expectations, are measured and …
reconsideration of how non-drug factors, like participant expectations, are measured and …
Network mechanisms of clinical response to transcranial magnetic stimulation in posttraumatic stress disorder and major depressive disorder
Background Repetitive transcranial magnetic stimulation (TMS) therapy can modulate
pathological neural network functional connectivity in major depressive disorder (MDD) …
pathological neural network functional connectivity in major depressive disorder (MDD) …
[HTML][HTML] The opioid system in depression
Opioid receptors are widely distributed throughout the brain and play an essential role in
modulating aspects of human mood, reward, and well-being. Accumulating evidence …
modulating aspects of human mood, reward, and well-being. Accumulating evidence …
Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches
Abstract The United States is in the midst of an opioid addiction and overdose crisis
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …
precipitated and exacerbated by use of prescription opioid medicines. The majority of opioid …
Pretreatment rostral anterior cingulate cortex theta activity in relation to symptom improvement in depression: a randomized clinical trial
Importance Major depressive disorder (MDD) remains challenging to treat. Although several
clinical and demographic variables have been found to predict poor antidepressant …
clinical and demographic variables have been found to predict poor antidepressant …
Placebo effects and neuromodulation for depression: a meta-analysis and evaluation of shared mechanisms
There is growing evidence that placebo effects can meaningfully modulate the brain.
However, there has been little consideration of whether these changes may overlap with …
However, there has been little consideration of whether these changes may overlap with …
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD).
However, only∼ 30% of patients experience adequate response after a single AD trial, and …
However, only∼ 30% of patients experience adequate response after a single AD trial, and …
Brain mechanisms of the placebo effect: an affective appraisal account
Placebos are sham medical treatments. Nonetheless, they can have substantial effects on
clinical outcomes. Placebos depend on a person's psychological and brain responses to the …
clinical outcomes. Placebos depend on a person's psychological and brain responses to the …
[HTML][HTML] Gut-brain axis: role of microbiome, metabolomics, hormones, and stress in mental health disorders
The influence of gut microbiome, metabolites, omics, hormones, and stress on general and
mental health is increasingly being recognized. Ancient cultures recognized the importance …
mental health is increasingly being recognized. Ancient cultures recognized the importance …