Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

With the goal of representing common denominators of aging in different organisms López-
Otín et al. in 2013 described nine hallmarks of aging. Since then, this representation has …

Aging leads to a high burden on society, both medically and economically. Cellular
senescence plays an essential role in the initiation of aging and age-related diseases …

Aging increases susceptibility both to psychiatric and medical disorders through a variety of
processes ranging from biochemical to pharmacologic to societal. Interactions between …

Covering: 2012 to 2023 The human population is aging. Thus, the greatest risk factor for
numerous diseases, such as diabetes, cancer and neurodegenerative disorders, is …

Background The growing trend of ageing population has become a worldwide concern. In
comparison with the youth, older people are more likely to suffer from multimorbidity and …

Patients with chronic liver disease (CLD) often present with significant frailty, sarcopenia,
and impaired immune function. However, the mechanisms driving the development of these …

Background: Alzheimer's disease (AD) is a serious neurodegenerative disease associated
with the memory and cognitive impairment. The occurrence of AD is due to the accumulation …

Background Osteoarthritis (OA) is a common chronic condition but its association with other
chronic conditions and mortality is largely unknown. This study aimed to use latent class …

The geroscience hypothesis proposes biological hallmarks of ageing are modifiable.
Increasing evidence supports targeting these hallmarks with therapeutics could prevent and …