[HTML][HTML] The MIC-1/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, cachexia, and other associated diseases
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth
factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified …
factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified …
GDF‐15 as a target and biomarker for diabetes and cardiovascular diseases: a translational prospective
Growth differentiation factor‐15 (GDF‐15) is a stress responsive cytokine. It is highly
expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular …
expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular …
[HTML][HTML] GDF15 provides an endocrine signal of nutritional stress in mice and humans
S Patel, A Alvarez-Guaita, A Melvin, D Rimmington… - Cell metabolism, 2019 - cell.com
GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific
hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity …
hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity …
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor α: a new model for anti-estrogen resistance
RA Campbell, P Bhat-Nakshatri, NM Patel… - Journal of Biological …, 2001 - ASBMB
Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and
uterine epithelial cells by binding to estrogen response elements in the promoter region of …
uterine epithelial cells by binding to estrogen response elements in the promoter region of …
[HTML][HTML] GDF15 induces anorexia through nausea and emesis
Summary Growth differentiation factor 15 (GDF15) is a cytokine that reduces food intake
through activation of hindbrain GFRAL-RET receptors and has become a keen target of …
through activation of hindbrain GFRAL-RET receptors and has become a keen target of …
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
T Kempf, A Zarbock, C Widera, S Butz, A Stadtmann… - Nature medicine, 2011 - nature.com
Inflammatory cell recruitment after myocardial infarction needs to be tightly controlled to
permit infarct healing while avoiding fatal complications such as cardiac rupture. Growth …
permit infarct healing while avoiding fatal complications such as cardiac rupture. Growth …
[PDF][PDF] GDF15: a hormone conveying somatic distress to the brain
GDF15 has recently gained scientific and translational prominence with the discovery that its
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain …
Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia
Growth differentiation factor 15 or macrophage inhibitory cytokine-1 (GDF15/MIC-1) is a
divergent member of the transforming growth factor β superfamily and has a diverse …
divergent member of the transforming growth factor β superfamily and has a diverse …
Systemic immunometabolism: challenges and opportunities
Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …
The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1
K Unsicker, B Spittau, K Krieglstein - Cytokine & growth factor reviews, 2013 - Elsevier
Abstract GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-β superfamily,
which is widely distributed in mammalian tissues and has been shown to play multiple roles …
which is widely distributed in mammalian tissues and has been shown to play multiple roles …