[HTML][HTML] Reconstitution of T cell subsets following allogeneic hematopoietic cell transplantation

L Dekker, C de Koning, C Lindemans, S Nierkens - Cancers, 2020‏ - mdpi.com
Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment
option for patients suffering from chemotherapy-refractory or relapsed hematological …

T‐cell receptor and B‐cell receptor repertoire profiling in adaptive immunity

A Minervina, M Pogorelyy… - Transplant International, 2019‏ - Wiley Online Library
B‐cell receptors and T‐cell receptors are the key molecules responsible for specific antigen
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …

Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse

S DeWolf, Y Elhanati, K Nichols, NR Waters… - Science translational …, 2023‏ - science.org
T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-
resident T cells at sites of pathology in human organs remains poorly understood. We …

The methods and advances of adaptive immune receptors repertoire sequencing

H Liu, W Pan, C Tang, Y Tang, H Wu… - …, 2021‏ - pmc.ncbi.nlm.nih.gov
The adaptive immune response is a powerful tool, capable of recognizing, binding to, and
neutralizing a vast number of internal and external threats via T or B lymphatic receptors with …

Immune reconstitution after allogeneic haematopoietic cell transplantation: from observational studies to targeted interventions

A Yanir, A Schulz, A Lawitschka, S Nierkens… - Frontiers in …, 2022‏ - frontiersin.org
Immune reconstitution (IR) after allogeneic haematopoietic cell transplantation (HCT)
represents a central determinant of the clinical post-transplant course, since the majority of …

Clinical and basic implications of dynamic T cell receptor clonoty** in hematopoietic cell transplantation

S Pagliuca, C Gurnari, S Hong, R Zhao… - JCI …, 2021‏ - pmc.ncbi.nlm.nih.gov
TCR repertoire diversification constitutes a foundation for successful immune reconstitution
after allogeneic hematopoietic cell transplantation (allo-HCT). Deep TCR Vβ sequencing of …

[HTML][HTML] High-Throughput immunogenetics for precision medicine in cancer

A Agathangelidis, E Vlachonikola, F Davi… - Seminars in cancer …, 2022‏ - Elsevier
Cancer is characterized by an extremely complex biological background, which hinders
personalized therapeutic interventions. Precision medicine promises to overcome this …

Potential of TCR sequencing in graft-versus-host disease

M Goel, A Eugster, J Schetelig, E Bonifacio… - Bone marrow …, 2023‏ - nature.com
Graft-versus-host disease (GvHD) remains one of the major complications following
allogeneic haematopoietic stem cell transplantation (allo-HSCT). GvHD can occur in almost …

Persistent T cell repertoire perturbation and T cell activation in HIV after long term treatment

CT Turner, J Brown, E Shaw, I Uddin, E Tsaliki… - Frontiers in …, 2021‏ - frontiersin.org
Objective In people living with HIV (PLHIV), we sought to test the hypothesis that long term
anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional …

Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation

S Buhler, F Bettens, C Dantin, S Ferrari-Lacraz… - Leukemia, 2020‏ - nature.com
After allogeneic hematopoietic stem cell transplantation (HSCT), immune reconstitution
leads to the development of a new T-cell repertoire. Immune reconstitution could be …