[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
Complement in neurological disorders and emerging complement-targeted therapeutics
The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …
[HTML][HTML] Longitudinal multi-omics of host–microbe dynamics in prediabetes
Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early
disease stages, its effects on biological processes or the transition to clinical T2D. To …
disease stages, its effects on biological processes or the transition to clinical T2D. To …
The role of the complement system in diabetic nephropathy
A Flyvbjerg - Nature Reviews Nephrology, 2017 - nature.com
The development of type 1 and type 2 diabetes mellitus has a substantial negative impact on
morbidity and mortality and is responsible for substantial individual and socioeconomic …
morbidity and mortality and is responsible for substantial individual and socioeconomic …
Diabetic nephropathy–is this an immune disorder?
GH Tesch - Clinical science, 2017 - portlandpress.com
Chronic diabetes is associated with metabolic and haemodynamic stresses which can
facilitate modifications to DNA, proteins and lipids, induce cellular dysfunction and damage …
facilitate modifications to DNA, proteins and lipids, induce cellular dysfunction and damage …
Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies
Introduction: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age
population of the developed world. DR encompasses a complex pathology, and one that is …
population of the developed world. DR encompasses a complex pathology, and one that is …
[HTML][HTML] Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus
Amplified inflammatory reaction has been observed to be involved in cardiometabolic
diseases such as obesity, insulin resistance, diabetes, dyslipidemia, and atherosclerosis …
diseases such as obesity, insulin resistance, diabetes, dyslipidemia, and atherosclerosis …
[HTML][HTML] Therapeutic targeting of the complement system in ocular disease
The complement system is involved in the pathogenesis of several ocular diseases,
providing a rationale for the investigation of complement-targeting therapeutics for these …
providing a rationale for the investigation of complement-targeting therapeutics for these …
Systems immunology of diabetes-tuberculosis comorbidity reveals signatures of disease complications
Comorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but
the pathological interactions between DM and TB remain incompletely understood. We …
the pathological interactions between DM and TB remain incompletely understood. We …
IgG glycan patterns are associated with type 2 diabetes in independent European populations
RFH Lemmers, M Vilaj, D Urda, F Agakov… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Background Type 2 diabetes results from interplay between genetic and acquired factors.
Glycans on proteins reflect genetic, metabolic and environmental factors. However …
Glycans on proteins reflect genetic, metabolic and environmental factors. However …