It is a sad fact that despite being almost completely preventable through human
papillomavirus (HPV) vaccination and screening, cervical cancer remains the fourth most …

Immune checkpoints consist of inhibitory and stimulatory pathways that maintain self-
tolerance and assist with immune response. In cancer, immune checkpoint pathways are …

Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …

Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

Immune cell functions are regulated by co-inhibitory and co-stimulatory receptors. The first
two generations of cancer immunotherapy agents consist primarily of antagonist antibodies …

Antibodies targeting costimulatory receptors of T cells have been developed for the
activation of T cell immunity in cancer immunotherapy. However, costimulatory molecule …

The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …

Ti3C2-MXene-based composites provide multifunctional interfaces in diagnosis and
treatment of tumors. Herein, we proposed a multifunctional nanoplatform based on Ti3C2 …

Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30%
of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led …