[HTML][HTML] The Role of Amphibian AMPs Against Oxidative Stress and Related Diseases

YL Silva Ortíz, TC de Sousa, NE Kruklis… - Antibiotics, 2025 - mdpi.com
Amphibians use their skin as an effective defense mechanism against predators and
microorganisms. Specialized glands produce antimicrobial peptides (AMPs) that possess …

The peptide salamandrin-I modulates components involved in pyroptosis and induces cell death in human leukemia cell line HL-60

AÉ Silva-Carvalho, NN Oliveira, JVL Machado… - Pharmaceutics, 2023 - mdpi.com
Amphibian secretions have been extensively investigated for the production of bioactive
molecules. Salamandrin-I is an antioxidant peptide, isolated from the skin secretion of the …

Antiviral action against SARS-CoV-2 of a synthetic peptide based on a Novel defensin present in the transcriptome of the fire salamander (Salamandra salamandra)

ALAN Barros, VC Silva, AF Ribeiro-Junior… - Pharmaceutics, 2024 - mdpi.com
The potential emergence of zoonotic diseases has raised significant concerns, particularly in
light of the recent pandemic, emphasizing the urgent need for scientific preparedness. The …

[HTML][HTML] Magainin-AM2 inhibits sucrose-induced hyperglycaemia, oxidative stress, and cognitive dysfunction in Drosophila melanogaster

A Adebowale, Z Oyaluna, AA Falobi, AO Abolaji… - Free Radical Biology …, 2024 - Elsevier
Hyperglycaemia-induced oxidative stress plays significant roles in the development of type 2
diabetes and its complications. This study investigates effects of magainin-AM2 on high …

Antioxidant and Neuroprotective Effects of the First Tryptophyllin Found in Snake Venom (Bothrops moojeni)

A Dematei, SR Costa, DC Moreira… - Journal of Natural …, 2022 - ACS Publications
In this study, we report the isolation, characterization, and synthesis of the peptide BmT-2
belonging to the tryptophyllins family, isolated from the venom of the snake Bothrops …

Novel tryptophyllin peptides from Physalaemus centralis inhibit oxidative stress-induced endothelial dysfunction in rat aorta preparation

A Nogueira, J Brango-Vanegas, AG Vasconcelos… - Toxicon, 2025 - Elsevier
Amphibian skin is a rich source of molecules with biotechnological potential, including the
tryptophyllin family of peptides. Here, we report the identification and characterization of two …

Albumin Redox Modifications Promote Cell Calcification Reflecting the Impact of Oxidative Status on Aortic Valve Disease and Atherosclerosis

T Sastre-Oliva, N Corbacho-Alonso… - Antioxidants, 2024 - mdpi.com
Calcific aortic valve disease (CAVD) and coronary artery disease (CAD) are related
cardiovascular diseases in which common mechanisms lead to tissue calcification …

Bioprospecting a Natural Antioxidant Peptide for Tomato Biostimulation Under Water Limitations: Physiological Approach

S Silva, C Teixeira, MC Dias, RB Pereira… - Journal of Plant Growth …, 2024 - Springer
Drought causes major agricultural losses, threatening food security worldwide. Thus,
innovative strategies have been explored to improve crop tolerance to drought. This work …

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms.

C ALBERTO-SILVA, B RUFINO DA SILVA - Biocell, 2024 - search.ebscohost.com
Venom snake-derived peptides have multiple biochemical, pharmacological, and
toxicological profiles, allowing for the discovery of new medicinal products and therapeutic …

Reactivity of amino acids and short peptide sequences: identifying bioactive compounds via DFT calculations

DF Oliveira, AP Coleone, FCDA Lima… - Molecular Diversity, 2024 - Springer
Bioactive peptides are short amino acid sequences that play important roles in various
physiological processes, including antioxidant and protective effects. These compounds can …