Despite international efforts to 'roll back malaria'the 2008 World Malaria Report revealed the
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …

Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

The mechanism of action of artemisinin and its derivatives, the most potent of the anti-
malarial drugs, is not completely understood. Here we present an unbiased chemical …

Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …

Pentacoordinate respiratory hemoproteins such as hemoglobin and myoglobin have
evolved to supply cells with oxygen. However, these respiratory heme proteins are also …

While plants produce reactive oxygen species (ROS) for stress signaling and pathogen
defense, they need to remove excessive ROS induced during stress responses in order to …

Rhabdomyolysis-induced renal failure represents up to 15% of all cases of acute renal
failure. Many studies over the past 4 decades have demonstrated that accumulation of …

Hydroxypyridinones (HPs) are a family of N-heterocyclic core chelators which, based on
their specific metal-coordination, easy manipulation/derivatization and biocompatibility, have …

Understanding the mechanism of action (MOA) of bioactive natural products will guide
endeavor to improve their cellular activities. Artemisinin and its derivatives inhibit cancer cell …

Oxidative stress plays an important role in the limited biological compatibility of many
biomaterials due to inflammation, as well as in various pathologies including atherosclerosis …