Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among
exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes …

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

Signal transducer and activator of transcription 3 (STAT3) is an attractive cancer therapeutic
target. Here we report the discovery of SD-36, a small-molecule degrader of STAT3. SD-36 …

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of
immune responses. However, its mechanisms of action remain poorly understood. Here, we …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …