The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

We are witnessing a stark increase in scientific interest in the neurobiological processes
associated with pregnancy and maternity. Convergent evidence suggests that around the …

The blood–brain barrier (BBB) prevents the brain uptake of most pharmaceuticals. This
property arises from the epithelial-like tight junctions within the brain capillary endothelium …

The blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes
from the brain∼ 100% of large-molecule neurotherapeutics and more than 98% of all small …

Hirsutism usually results from a subtle excess of androgens. As such, it is a clue to possible
endocrine disturbance in addition to presenting cosmetic problems. We use the term …

Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry.
However, this growth is blocked by the problem of the blood–brain barrier (BBB). Essentially …

Testosterone is one of the most potent naturally secreted androgenicanabolic hormones,
and its biological effects include promotion of muscle growth. In muscle, testosterone …

A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis,
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …

The free hormone hypothesis states that the biological activity of a given hormone is affected
by its unbound (free) rather than protein-bound concentration in the plasma. The …