The cloning of the founding member of the Hedgehog (HH) family of secreted proteins two
decades ago inaugurated a field that has diversified to encompass embryonic development …

The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …

The aggregation of misfolded proteins is associated with the perturbation of cellular function,
ageing and various human disorders. Mounting evidence suggests that protein aggregation …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …

Centrosome amplification is a hallmark of cancer. However, despite significant progress in
recent years, we are still far from understanding how centrosome amplification affects …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Intracellular and extracellular accumulation of aggregated protein are linked to many
diseases, including ageing-related neurodegeneration and systemic amyloidosis. Cells …

Intracellular deposition of aggregated and ubiquitylated proteins is a prominent
cytopathological feature of most neurodegenerative disorders. Whether protein aggregates …

Each protein must be synthesized with the correct amino acid sequence, folded into its
native structure, and transported to a relevant subcellular location and protein complex. If …