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Roles of neutrophils in glioma and brain metastases
Neutrophils, which are the most abundant circulating leukocytes in humans, are the first line
of defense against bacterial and fungal infections. Recent studies have reported the role and …
of defense against bacterial and fungal infections. Recent studies have reported the role and …
Interleukins in glioblastoma pathophysiology: implications for therapy
YT Yeung, KL McDonald, T Grewal… - British journal of …, 2013 - Wiley Online Library
Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …
Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer
agents which target residual tumor cells by bypassing the blood-brain barrier has been a …
agents which target residual tumor cells by bypassing the blood-brain barrier has been a …
A nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival
Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to
upregulation of O 6-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was …
upregulation of O 6-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was …
Targeting Tregs in malignant brain cancer: overcoming IDO
One of the hallmark features of glioblastoma multiforme (GBM), the most common adult
primary brain tumor with a very dismal prognosis, is the accumulation of CD4+ CD25+ …
primary brain tumor with a very dismal prognosis, is the accumulation of CD4+ CD25+ …
A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme
Abstract Development of temozolomide (TMZ) resistance contributes to the poor prognosis
for glioblastoma multiforme (GBM) patients. It was previously demonstrated that delivery of …
for glioblastoma multiforme (GBM) patients. It was previously demonstrated that delivery of …
Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma
Although temozolomide (TMZ) is the current first-line chemotherapy for glioblastoma
multiforme (GBM), most patients either do not respond or ultimately fail TMZ treatment. Both …
multiforme (GBM), most patients either do not respond or ultimately fail TMZ treatment. Both …
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma
Background Glioblastoma (GBM) is a poorly immunogenic neoplasm treated with focused
radiation. Immunotherapy has demonstrated synergistic survival effects with stereotactic …
radiation. Immunotherapy has demonstrated synergistic survival effects with stereotactic …
[HTML][HTML] The future of glioblastoma therapy: synergism of standard of care and immunotherapy
The current standard of care for glioblastoma (GBM) is maximal surgical resection with
adjuvant radiotherapy and temozolomide (TMZ). As the 5-year survival with GBM remains at …
adjuvant radiotherapy and temozolomide (TMZ). As the 5-year survival with GBM remains at …
Knockdown of long noncoding RNA H19 sensitizes human glioma cells to temozolomide therapy
P Jiang, P Wang, X Sun, Z Yuan, R Zhan… - OncoTargets and …, 2016 - Taylor & Francis
Temozolomide (TMZ) is commonly used in glioma chemotherapy. However, a great clinical
challenge for TMZ is chemoresistance. H19 transcripts are recognized as long noncoding …
challenge for TMZ is chemoresistance. H19 transcripts are recognized as long noncoding …