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[HTML][HTML] Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …
diverse molecular compounds and has become an important synthetic tool in different fields …
Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs
The focus of the review is to discuss the relevant and essential aspects of pharmaceutical
cocrystals in both academia and industry with an emphasis on non-steroidal anti …
cocrystals in both academia and industry with an emphasis on non-steroidal anti …
Design and synthesis of isoniazid-based pyrazolines as potential inhibitors of Mycobacterium tuberculosis with promising radical scavenging action: in-vitro and in …
J Rasgania, R Gavadia, M Varma-Basil… - Journal of Molecular …, 2024 - Elsevier
In view of the devastating tuberculosis infections and emerging resistance against available
drugs, novel 5-phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl) …
drugs, novel 5-phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl) …
Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes
Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered
area for host cell response. Therefore, biofilms provide troubles in fields such as medicine …
area for host cell response. Therefore, biofilms provide troubles in fields such as medicine …
Facile synthesis, pharmacological and In silico analysis of succinimide derivatives: An approach towards drug discovery
The hybrid heterocyclic scaffolds possess extensive medicinal values and significant
pharmaceutical usage. A series of N-substituted-2, 5-dioxopyrrolidine carboxamides …
pharmaceutical usage. A series of N-substituted-2, 5-dioxopyrrolidine carboxamides …
Design, synthesis and exploration of novel triazinoindoles as potent quorum-sensing inhibitors and radical quenchers
J Rasgania, R Gavadia, N Sahu, P Sharma… - Future Medicinal …, 2024 - Taylor & Francis
Background: Antimicrobial resistance has become a critical health concern, and quorum-
sensing exacerbates the resistance by facilitating cell-to-cell communication within the …
sensing exacerbates the resistance by facilitating cell-to-cell communication within the …
Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
In this study, we reported the synthesis of a new series of Silver (I)-N-heterocyclic carbene
complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) …
complexes which were obtained from the corresponding new N-heterocyclic carbene (NHC) …
Design and synthesis of triazole-functionalized isatin hybrids with potent anti-proliferative action against triple-negative breast cancer MDA-MB-231 cell line: a hybrid …
Abstract Differently substituted novel 1-(2-((aryl-4 H-1, 2, 4-triazol-3-yl) thio) acetyl) indoline-
2, 3-diones have been synthesized, geometrically optimized, and examined for global …
2, 3-diones have been synthesized, geometrically optimized, and examined for global …
'Charge Reverse'Halogen Bonding Contacts in Metal-Organic Multi-Component Compounds: Antiproliferative Evaluation and Theoretical Studies
Two new metal–organic multi-component compounds of Ni (II) and Co (II), viz.[Ni (3-CNpy) 2
(H2O) 4] ADS· 2.75 H2O (1) and [Co (3-CNpy) 2 (H2O) 4](4-ClbzSO3) 2 (2)(3-CNpy= 3 …
(H2O) 4] ADS· 2.75 H2O (1) and [Co (3-CNpy) 2 (H2O) 4](4-ClbzSO3) 2 (2)(3-CNpy= 3 …
In acid-aminopyrimidine continuum: experimental and computational studies of furan tetracarboxylate-2-aminopyrimidinium salt
Salts and cocrystals are the two important solid forms when a carboxylic acid crystallizes
with an aminopyrimidine base such that the extent of proton transfer distinguishes between …
with an aminopyrimidine base such that the extent of proton transfer distinguishes between …