Assembly, heterogeneity, and breaching of the basement membranes
Basement membranes are thin sheets of self-assembled extracellular matrices that are
essential for embryonic development and for the homeostasis of adult tissues. They play a …
essential for embryonic development and for the homeostasis of adult tissues. They play a …
Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from
the stroma. This barrier must be breached to allow dissemination of the tumor cells to …
the stroma. This barrier must be breached to allow dissemination of the tumor cells to …
Develo** an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions
M Verhulsel, A Simon, M Bernheim-Dennery… - Lab on a Chip, 2021 - pubs.rsc.org
Organoids are widely used as a model system to study gut pathophysiology; however, they
fail to fully reproduce the complex, multi-component structure of the intestinal wall. We …
fail to fully reproduce the complex, multi-component structure of the intestinal wall. We …
A catalog of numerical centrosome defects in epithelial ovarian cancers
JP Morretton, A Simon, A Herbette… - EMBO Molecular …, 2022 - embopress.org
Centrosome amplification, the presence of more than two centrosomes in a cell is a common
feature of most human cancer cell lines. However, little is known about centrosome numbers …
feature of most human cancer cell lines. However, little is known about centrosome numbers …
A new front in cell invasion: the invadopodial membrane
Invadopodia are F-actin-rich membrane protrusions that breach basement membrane
barriers during cell invasion. Since their discovery more than 30 years ago, invadopodia …
barriers during cell invasion. Since their discovery more than 30 years ago, invadopodia …
The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane
DS Costa, IW Kenny-Ganzert, Q Chi, K Park… - …, 2023 - journals.biologists.com
Cell invasion through basement membrane (BM) barriers is important in development,
immune function and cancer progression. As invasion through BM is often stochastic …
immune function and cancer progression. As invasion through BM is often stochastic …
Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans
LC Kelley, Z Wang, EJ Hagedorn, L Wang, W Shen… - nature protocols, 2017 - nature.com
Cell invasion through basement membrane (BM) barriers is crucial in development,
leukocyte trafficking and the spread of cancer. The mechanisms that direct invasion, despite …
leukocyte trafficking and the spread of cancer. The mechanisms that direct invasion, despite …
GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA
The invasive properties of cancer cells are intimately linked to their mechanical phenotype,
which can be regulated by intracellular biochemical signalling. Cell contractility, induced by …
which can be regulated by intracellular biochemical signalling. Cell contractility, induced by …
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting
The shape of cellular membranes is highly regulated by a set of conserved mechanisms that
can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma …
can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma …
Angiogenesis invasion assay to study endothelial cell invasion and sprouting behavior
Y Dong, F Alonso, T Jahjah, I Fremaux… - Cell Migration in Three …, 2023 - Springer
Angiogenesis is the formation of new blood vessels from the existing vasculature. It is a
fundamental process in developmental biology but also a pathological event that initiates or …
fundamental process in developmental biology but also a pathological event that initiates or …