The discovery of the first neurotransmitter—acetylcholine—was soon followed by the
discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase …

Since the discovery of the cholinergic deficit in Alzheimer disease (AD), acetylcholinesterase
(AChE) has been widely investigated in tissues involved in the disease. These studies …

A common feature in the Alzheimer's disease (AD) brain is the presence of
acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and …

The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately
50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level …

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP
NL-GF) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …

Organophosphorus compounds are potent neurotoxic chemicals that are widely used in
medicine, industry, and agriculture. The neurotoxicity of these chemicals has been …

Bacopa monniera and Ginkgo biloba are well-known cognitive enhancers in Indian and
Chinese traditional medicine systems. Standardized extracts of B. monniera and G. biloba …

Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which
are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal …

Data found in literature have reported that bacterial endotoxins may be involved in the
inflammatory and pathological processes associated with amyloidosis and Alzheimer's …

Acetylcholinesterase (AChE; EC 3.1. 1.7) plays a crucial role in the rapid hydrolysis of the
neurotransmitter acetylcholine, in the central and peripheral nervous system and might also …