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The information theory of aging
YR Lu, X Tian, DA Sinclair - Nature aging, 2023 - nature.com
Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …
Stem cell systems and regeneration in planaria
JC Rink - Development genes and evolution, 2013 - Springer
Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …
types that form the human body is a central problem of basic and medical science. The …
Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment
JC Van Wolfswinkel, DE Wagner, PW Reddien - Cell stem cell, 2014 - cell.com
Planarians are flatworms capable of regenerating any missing body region. This capacity is
mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells …
mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells …
The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms
MA Grohme, S Schloissnig, A Rozanski, M Pippel… - Nature, 2018 - nature.com
The planarian Schmidtea mediterranea is an important model for stem cell research and
regeneration, but adequate genome resources for this species have been lacking. Here we …
regeneration, but adequate genome resources for this species have been lacking. Here we …
Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth
Á Varley, HR Horkan, ET McMahon, G Krasovec… - Current Biology, 2023 - cell.com
In most animals, pluripotency is irreversibly lost post gastrulation. By this stage, all
embryonic cells have already committed either to one of the somatic lineages (ectoderm …
embryonic cells have already committed either to one of the somatic lineages (ectoderm …
Annelid adult cell type diversity and their pluripotent cellular origins
P Álvarez-Campos, H García-Castro, E Emili… - Nature …, 2024 - nature.com
Many annelids can regenerate missing body parts or reproduce asexually, generating all
cell types in adult stages. However, the putative adult stem cell populations involved in these …
cell types in adult stages. However, the putative adult stem cell populations involved in these …
RNA interference by feeding in vitro–synthesized double‐stranded RNA to planarians: Methodology and dynamics
L Rouhana, JA Weiss, DJ Forsthoefel… - Developmental …, 2013 - Wiley Online Library
Background The ability to assess gene function is essential for understanding biological
processes. Currently, RNA interference (RNAi) is the only technique available to assess …
processes. Currently, RNA interference (RNAi) is the only technique available to assess …
Adult somatic stem cells in the human parasite Schistosoma mansoni
JJ Collins III, B Wang, BG Lambrus, ME Tharp, H Iyer… - Nature, 2013 - nature.com
Schistosomiasis is among the most prevalent human parasitic diseases, affecting more than
200 million people worldwide. The aetiological agents of this disease are trematode …
200 million people worldwide. The aetiological agents of this disease are trematode …
Aging and longevity in the simplest animals and the quest for immortality
RS Petralia, MP Mattson, PJ Yao - Ageing research reviews, 2014 - Elsevier
Here we review the examples of great longevity and potential immortality in the earliest
animal types and contrast and compare these to humans and other higher animals. We start …
animal types and contrast and compare these to humans and other higher animals. We start …