Toll-like receptors, associated biological roles, and signaling networks in non-mammals

L Nie, SY Cai, JZ Shao, J Chen - Frontiers in immunology, 2018 - frontiersin.org
The innate immune system is the first line of defense against pathogens, which is initiated by
the recognition of pathogen-associated molecular patterns (PAMPs) and endogenous …

A beginner's guide to eukaryotic genome annotation

M Yandell, D Ence - Nature Reviews Genetics, 2012 - nature.com
The falling cost of genome sequencing is having a marked impact on the research
community with respect to which genomes are sequenced and how and where they are …

BRAKER2: automatic eukaryotic genome annotation with GeneMark-EP+ and AUGUSTUS supported by a protein database

T Brůna, KJ Hoff, A Lomsadze, M Stanke… - NAR genomics and …, 2021 - academic.oup.com
The task of eukaryotic genome annotation remains challenging. Only a few genomes could
serve as standards of annotation achieved through a tremendous investment of human …

Whole-genome annotation with BRAKER

KJ Hoff, A Lomsadze, M Borodovsky… - Gene prediction: methods …, 2019 - Springer
BRAKER is a pipeline for highly accurate and fully automated gene prediction in novel
eukaryotic genomes. It combines two major tools: GeneMark-ES/ET and AUGUSTUS …

GeneMark-ETP significantly improves the accuracy of automatic annotation of large eukaryotic genomes

T Brůna, A Lomsadze, M Borodovsky - Genome Research, 2024 - genome.cshlp.org
Large-scale genomic initiatives, such as the Earth BioGenome Project, require efficient
methods for eukaryotic genome annotation. Here we present an automatic gene finder …

MAKER2: an annotation pipeline and genome-database management tool for second-generation genome projects

C Holt, M Yandell - BMC bioinformatics, 2011 - Springer
Background Second-generation sequencing technologies are precipitating major shifts with
regards to what kinds of genomes are being sequenced and how they are annotated. While …

Combining RNA-seq data and homology-based gene prediction for plants, animals and fungi

J Keilwagen, F Hartung, M Paulini, SO Twardziok… - BMC …, 2018 - Springer
Background Genome annotation is of key importance in many research questions. The
identification of protein-coding genes is often based on transcriptome sequencing data, ab …

[HTML][HTML] Review on the computational genome annotation of sequences obtained by next-generation sequencing

GF Ejigu, J Jung - Biology, 2020 - mdpi.com
Simple Summary Due to the development of high-throughput sequencing technologies,
computational genome annotation of sequences has become one of the principal research …

Evolutionary origins of toll-like receptor signaling

JJ Brennan, TD Gilmore - Molecular biology and evolution, 2018 - academic.oup.com
Toll-like receptors (TLRs) are transmembrane pattern recognition receptors that are best
known for their roles in innate immunity for the detection of and defense against microbial …

Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species

JH Werren, S Richards, CA Desjardins, O Niehuis… - Science, 2010 - science.org
We report here genome sequences and comparative analyses of three closely related
parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are …