Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Because of their intrinsic physiochemical and biological properties together with essential
role in living organism, copper (Cu) and Cu-based nanomaterials have garnered …

Nanomaterials offer unique physical, chemical and biological properties of interest for
medical imaging and therapy. Over the last two decades, there has been an increasing effort …

Background and Aims IL‐6–induced tumor progression has been well established through
the induction of antiapoptotic and proliferative genes. However, whether other mechanisms …

The integration of nuclear imaging with nanomedicine is a powerful tool for efficient
development and clinical translation of liposomal drug delivery systems. Furthermore, it may …

Copper is a necessary micronutrient for maintaining the well-being of the human body. The
biological activity of organic ligands, especially their anticancer activity, is often enhanced …

Copper is required for cancer cell proliferation and tumor angiogenesis. Copper-64
radionuclide (64Cu), a form of copper chloride (64CuCl2), is rapidly emerging as a …

Highlights•Copper radionuclides for in vivo imaging of biological functions of copper
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …

Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …