The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Bone defects repair and regeneration by various causes such as tumor resection, trauma,
degeneration, etc. have always been a key issue in the clinics. As one of the few organs that …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

Aortic valve stenosis due to calcification of the valve leaflets is the most common valve
disease in the developed world. It is the third leading cause of cardiovascular disease. 1 …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

The standard procedure for the osteogenic differentiation of multipotent stem cells is
treatment of a confluent monolayer with a cocktail of dexamethasone (Dex), ascorbic acid …

Transcription factors (TFs) can define distinct cellular identities despite nearly identical DNA-
binding specificities. One mechanism for achieving regulatory specificity is DNA-guided TF …