Structure-bioactivity relationships of methylxanthines: Trying to make sense of all the promises and the drawbacks
Methylxanthines are a group of phytochemicals derived from the purine base xanthine and
obtained from plant secondary metabolism. They are unobtrusively included in daily diet in …
obtained from plant secondary metabolism. They are unobtrusively included in daily diet in …
Adenosine receptor antagonists: Recent advances and therapeutic perspective
Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …
Xanthine scaffold: scope and potential in drug development
Medicinal plants have been the basis for discovery of various important marketed drugs.
Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline …
Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline …
Pharmacological potential of methylxanthines: Retrospective analysis and future expectations
Methylated xanthines (methylxanthines) are available from a significant number of different
botanical species. They are ordinarily included in daily diet, in many extremely common …
botanical species. They are ordinarily included in daily diet, in many extremely common …
Anti-obesity potential of natural methylxanthines
Obesity is one of the most challenging health issue worldwide that has been steadily
increasing in the last decades. Obesity arises from a positive energy balance in result of …
increasing in the last decades. Obesity arises from a positive energy balance in result of …
Synthesis of some novel 8-(4-Alkylpiperazinyl) caffeine derivatives as potent anti-Leishmania agents
In this paper, the synthesis, characterization and the leishmanicidal assessments of novel 8-
(4-alkylpiperazinyl) caffeine derivatives have been described. These compounds are new …
(4-alkylpiperazinyl) caffeine derivatives have been described. These compounds are new …
Recent Advances in the Synthesis of Xanthines: A Short Review
Xanthine and its derivatives are considered a pharmacologically potential moiety that
manifests immense biological activities. Owing to this much diversity in the biological field …
manifests immense biological activities. Owing to this much diversity in the biological field …
5-Substituted 2-benzylidene-1-tetralone analogues as A1 and/or A2A antagonists for the potential treatment of neurological conditions
Abstract Adenosine A 1 and A 2A receptors are attracting great interest as drug targets for
their role in cognitive and motor deficits, respectively. Antagonism of both these adenosine …
their role in cognitive and motor deficits, respectively. Antagonism of both these adenosine …
Evaluation of 2‐benzylidene‐1‐tetralone derivatives as antagonists of A1 and A2A adenosine receptors
Antagonists of the adenosine receptors (A1 and A2A) are thought to be beneficial in
neurological disorders, such as Alzheimer's and Parkinson's disease. The aim of this study …
neurological disorders, such as Alzheimer's and Parkinson's disease. The aim of this study …
Methoxy substituted 2-benzylidene-1-indanone derivatives as A 1 and/or A 2A AR antagonists for the potential treatment of neurological conditions
A prior study reported on hydroxy substituted 2-benzylidene-1-indanone derivatives as A1
and/or A2A antagonists for the potential treatment of neurological conditions. A lead …
and/or A2A antagonists for the potential treatment of neurological conditions. A lead …