For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

RUNX2 is an essential transcription factor for osteoblast differentiation and chondrocyte
maturation. SP7, another transcription factor, is required for osteoblast differentiation. Major …

Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …

With successful extraction of growth factors and bone morphogenic proteins (BMPs) from
mammalian teeth, many researchers have supported development of a bone substitute …

In recent years, much progress has been made in understanding the factors that regulate the
gene expression program that underlies the induction, proliferation, differentiation, and …

Osteosarcoma is the most common malignant bone tumour, with a peak incidence in
children and young adolescents, suggesting a role of rapid bone growth in its pathogenesis …

Background: In the clinical field of jawbone formation, the use of autogenous bone as the
graft material is the gold standard. However, there are some problems with this technique …

The Wnt signaling pathway plays key roles in differentiation and development and
alterations in this signaling pathway are causally associated with numerous human …

Mechanical loading is of pivotal importance in the maintenance of skeletal homeostasis, but
the players involved in the transduction of mechanical stimuli to promote bone maintenance …

Bone formation occurs by two distinct mechanisms, namely, periosteal ossification and
endochondral ossification. In both mechanisms, osteoblasts play an important role in the …