Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial
and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to …

Many clinically useful antibiotics exert their antimicrobial effects by blocking protein
synthesis on the bacterial ribosome. The structure of the ribosome has recently been …

This paper describes the current update on macromolecular model validation services that
are provided at the MolProbity website, emphasizing changes and additions since the …

Abstract Background The 16S rRNA gene is used extensively in bacterial phylogenetics, in
species delineation, and now widely in microbiome studies. However, the gene suffers from …

Although the mode of action of the ribosomes, the multi-component universal effective
protein-synthesis organelles, has been thoroughly explored, their mere appearance …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …

Insight into the three-dimensional architecture of RNA is essential for understanding its
cellular functions. However, even the classic transfer RNA structure contains features that …

Identifying relationships between function, amino acid sequence, and protein structure
represents a major challenge. In this study, we propose a bioinformatics approach that …

How did specific useful protein sequences arise from simpler molecules at the origin of life?
This seemingly needle-in-a-haystack problem has remarkably close resemblance to the old …

Ribosomes, which are central to protein synthesis and convert transcribed mRNAs into
polypeptide chains, have been the focus of structural and biochemical studies for more than …