Technological developments in lncRNA biology

S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

RNA biomarkers: frontier of precision medicine for cancer

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[HTML][HTML] In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs

L Sun, P Li, X Ju, J Rao, W Huang, L Ren, S Zhang… - Cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic. Understanding of the RNA virus and its …

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

C Chen, Y Luo, W He, Y Zhao, Y Kong… - The Journal of …, 2020 - Am Soc Clin Investig
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an
extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN …

Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

D Hanniford, A Ulloa-Morales, A Karz… - Cancer cell, 2020 - cell.com
Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms
governing metastatic spread may uncover important tumor biology and/or yield promising …

POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins

W Zhao, S Zhang, Y Zhu, X **, P Bao, Z Ma… - Nucleic Acids …, 2022 - academic.oup.com
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation. Accurate
identification of RBP binding sites in multiple cell lines and tissue types from diverse species …

Accurate quantification of circular RNAs identifies extensive circular isoform switching events

J Zhang, S Chen, J Yang, F Zhao - Nature communications, 2020 - nature.com
Detection and quantification of circular RNAs (circRNAs) face several significant challenges,
including high false discovery rate, uneven rRNA depletion and RNase R treatment …

Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins

EL Van Nostrand, GA Pratt, BA Yee, EC Wheeler… - Genome biology, 2020 - Springer
Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation …