Immunotoxins (ITs) are attractive anticancer modalities aimed at cancer-specific delivery of
highly potent cytotoxic protein toxins. An IT consists of a targeting domain (an antibody …

In the past decades, for the intermediate or advanced cancerous stages, preclinical and
clinical applications of nanomedicines in cancer theranostics have been extensively studied …

Immunotoxins (ITXs) are chimeric molecules that combine the specificity of a targeting
domain, usually derived from an antibody, and the cytotoxic potency of a toxin, leading to the …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

In cancer treatment, polymeric nanoparticles (NPs) can serve as a vehicle for the delivery of
cytotoxic proteins that have intracellular targets but that lack well-defined mechanisms for …

Cancer cells frequently upregulate surface receptors that promote growth and survival.
These receptors constitute valid targets for intervention. One strategy involves the delivery of …

Photochemical internalization (PCI) is a further development of photodynamic therapy
(PDT). In this report, we describe PCI as a potential tool for cellular internalization of …

Immunotoxins (ITs) are protein-based drugs that compose of targeting and cytotoxic
moieties. After binding the IT to the specific cell-surface antigen, the IT internalises into the …

Bifunctional proteins (BFPs) are a class of therapeutic agents produced through genetic
engineering and protein engineering, and are increasingly used to treat various human …

Immunotoxins do not only bind to cancer-specific receptors to mediate the elimination of
tumor cells through the innate immune system, but also increase target cytotoxicity by the …