[HTML][HTML] Beyond t test and ANOVA: applications of mixed-effects models for more rigorous statistical analysis in neuroscience research
In basic neuroscience research, data are often clustered or collected with repeated
measures, hence correlated. The most widely used methods such as t test and ANOVA do …
measures, hence correlated. The most widely used methods such as t test and ANOVA do …
Hypertension Canada's 2020 comprehensive guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children
Hypertension Canada's 2020 guidelines for the prevention, diagnosis, risk assessment, and
treatment of hypertension in adults and children provide comprehensive, evidence-based …
treatment of hypertension in adults and children provide comprehensive, evidence-based …
Investigating the replicability of preclinical cancer biology
Replicability is an important feature of scientific research, but aspects of contemporary
research culture, such as an emphasis on novelty, can make replicability seem less …
research culture, such as an emphasis on novelty, can make replicability seem less …
Challenges for assessing replicability in preclinical cancer biology
We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …
preclinical research in cancer biology. The initial aim of the project was to repeat 193 …
Guidelines for reporting trial protocols and completed trials modified due to the COVID-19 pandemic and other extenuating circumstances: the CONSERVE 2021 …
Importance Extenuating circumstances can trigger unplanned changes to randomized trials
and introduce methodological, ethical, feasibility, and analytical challenges that can …
and introduce methodological, ethical, feasibility, and analytical challenges that can …
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta …
Background Intrahepatic cholestasis of pregnancy is associated with adverse perinatal
outcomes, but the association with the concentration of specific biochemical markers is …
outcomes, but the association with the concentration of specific biochemical markers is …
[HTML][HTML] A manifesto for reproducible science
Improving the reliability and efficiency of scientific research will increase the credibility of the
published scientific literature and accelerate discovery. Here we argue for the adoption of …
published scientific literature and accelerate discovery. Here we argue for the adoption of …
Taxonomy of approaches to develo** interventions to improve health: a systematic methods overview
Background Interventions need to be developed prior to the feasibility and piloting phase of
a study. There are a variety of published approaches to develo** interventions …
a study. There are a variety of published approaches to develo** interventions …
Progress in evidence-based medicine: a quarter century on
In response to limitations in the understanding and use of published evidence, evidence-
based medicine (EBM) began as a movement in the early 1990s. EBM's initial focus was on …
based medicine (EBM) began as a movement in the early 1990s. EBM's initial focus was on …
[PDF][PDF] How to design vector control efficacy trials: guidance on phase III vector control field trial design provided by the Vector Control Advisory Group
World Health Organization - 2017 - apps.who.int
Vector-borne diseases (VBDs), including malaria, dengue and leishmaniasis, cause
considerable morbidity and mortality in tropical regions of the world. Vector control methods …
considerable morbidity and mortality in tropical regions of the world. Vector control methods …