Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic
cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be …

Trained immunity is an innate immune memory response that is induced by a primary
inflammatory stimulus that sensitizes monocytes and macrophages to a secondary …

The recognition of pathogens to which we are constantly exposed induces the immediate
replenishment of innate immune cells from the most primitive stages of their development …

Abstract Type I interferon (IFN-I)-mediated antiviral responses are central to host defense
against viral infections. Crucial is the tight and well-orchestrated control of cellular decision …

In contrast to adaptive immunity, which relies on memory T and B cells for long-term
pathogen-specific responses, trained immunity involves the enhancement of innate immune …

Once perceived to be homogenous effector cells, neutrophils have since been shown to
exhibit population heterogeneity. Here, we established an experimental model of clonal …

Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic
cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be …

Objective Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory disease of
unknown etiology, mainly affecting synovial joints, resulting in severe pain, stiffness, limited …

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer with precursor B-
cell ALL (pB-ALL) accounting for~ 85% of the cases. Childhood pB-ALL development is …