The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …

Hemogenic endothelium is a specialized subset of develo** vascular endothelium that
acquires hematopoietic potential and can give rise to multilineage hematopoietic stem and …

NOTCH signaling is required for the arterial specification and formation of hematopoietic
stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad …

Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells
(HSPCs) essential for establishment and maintenance of the adult blood system. This …

The formation and remodeling of a functional circulatory system is critical for sustaining
prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells …

All haematopoietic cell lineages that circulate in the blood of adult mammals derive from
multipotent haematopoietic stem cells (HSCs). By contrast, in the blood of mammalian …

Hematopoietic stem cells (HSCs) have extensive regenerative capacity to replace all blood
cell types, an ability that is harnessed in the clinic for bone marrow transplantation. Finding …

Pluripotent stem cells (PSC s) such as embryonic stem cells or induced pluripotent stem
cells represent a promising cell type to gain novel insights into human biology …

Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate
mature blood lineages throughout life. They, together with hematopoietic progenitor cells …

Hematopoietic stem and progenitor cells (HSPCs) are capable of producing all mature blood
lineages, as well as maintaining the self-renewal ability throughout life. The hairy-like …