Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Importance It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are
at greater risk of develo** Alzheimer disease (AD) than men, and the sex-dependent …

Neurodegenerative diseases including Alzheimer (AD) and Parkinson (PD) have attracted
attention in last decades due to their high incidence worldwide. The etiology of these …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of …

Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is
considerable research interest in understanding whether APOE-ε4 influences cognition in …

Autosomal dominant Alzheimer's disease (ADAD) is genetically determined, but variability in
age of symptom onset suggests additional factors may influence cognitive trajectories …

Background The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of
the most important known risk factors for develo** Alzheimer disease (AD). The diagnosis …

Importance While amyloid and neurodegeneration are viewed together as Alzheimer
disease pathophysiology (ADP), the factors that influence amyloid and AD-pattern …