Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Myelin, the membrane surrounding neuronal axons, is critical for central nervous system
(CNS) function. Injury to myelin-forming oligodendrocytes (OL) in chronic neurological …

In the develo** central nervous system, oligodendrocyte precursor cells (OPCs)
differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and …

Regulation of myeloid cell activity is critical for successful myelin regeneration
(remyelination) in demyelinating diseases, such as multiple sclerosis (MS). Here, we show …

Multiple sclerosis (MS) is a neurological and inflammatory autoimmune disease of the
Central Nervous System in which selective activation of T and B lymphocytes prompts a …

Introduction Five to eight percent of the world population currently suffers from at least one
autoimmune disorder. Despite multiple immune modulatory therapies for autoimmune …

Background and Objectives People with multiple sclerosis (MS) have a dysregulated
circulating metabolome, but the metabolome of MS brain lesions has not been studied. The …

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by
antiplatelet autoantibodies, thrombocytopenia, and bleeding, however, its treatment options …