ABSTRACT BACKGROUND AND PURPOSE Spinal cord atrophy (SCA) is an important
emerging outcome measure in multiple sclerosis (MS); however, there is limited consensus …

The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …

Abstract See Stankoff and Louapre (doi: 10.1093/brain/awy114) for a scientific commentary
on this article. Grey matter atrophy is present from the earliest stages of multiple sclerosis …

In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of
administration, the safety and the clinical efficacy of mesenchymal stem cell (MSC) …

Although multiple sclerosis has traditionally been considered a white matter disease,
extensive research documents the presence and importance of grey matter injury including …

Spinal cord MRI is not routinely performed for multiple sclerosis (MS) monitoring. Here, we
explored whether spinal cord MRI activity offers any added value over brain MRI activity for …

Introduction Multiple sclerosis (MS) is characterised by the accumulation of permanent
neurological disability secondary to irreversible tissue loss (neurodegeneration) in the brain …

Objectives To stratify patients with multiple sclerosis (pwMS) based on brain MRI-derived
volumetric features using unsupervised machine learning. Methods The 3-T brain MRIs of …

Background: Little is known on longer term changes of spinal cord volume (SCV) in primary
progressive multiple sclerosis (PPMS). Objective: Longitudinal evaluation of SCV loss in …

CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with
disease progression, but the pathogenic role and antigenic targets of these clonally …