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Sperm defects in primary ciliary dyskinesia and related causes of male infertility
The core axoneme structure of both the motile cilium and sperm tail has the same
ultrastructural 9+ 2 microtubular arrangement. Thus, it can be expected that genetic defects …
ultrastructural 9+ 2 microtubular arrangement. Thus, it can be expected that genetic defects …
Genetics of male infertility
Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …
Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study
J Lord, DJ McMullan, RY Eberhardt, G Rinck… - The Lancet, 2019 - thelancet.com
Background Fetal structural anomalies, which are detected by ultrasonography, have a
range of genetic causes, including chromosomal aneuploidy, copy number variations …
range of genetic causes, including chromosomal aneuploidy, copy number variations …
Major regulatory mechanisms involved in sperm motility
The genetic bases and molecular mechanisms involved in the assembly and function of the
flagellum components as well as in the regulation of the flagellar movement are not fully …
flagellum components as well as in the regulation of the flagellar movement are not fully …
Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism
Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key
roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein …
roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein …
Morphological and molecular bases of male infertility: a closer look at sperm flagellum
Infertility is a major health problem worldwide without an effective therapy or cure. It is
estimated to affect 8–12% of couples in the reproductive age group, equally affecting both …
estimated to affect 8–12% of couples in the reproductive age group, equally affecting both …
Genomic imprinting-like monoallelic paternal expression determines sex of channel catfish
The X and Y chromosomes of channel catfish have the same gene contents. Here, we report
allelic hypermethylation of the X chromosome within the sex determination region (SDR) …
allelic hypermethylation of the X chromosome within the sex determination region (SDR) …
The X chromosome and male infertility
The X chromosome is a key player in germ cell development, as has been highlighted for
males in previous studies revealing that the mammalian X chromosome is enriched in genes …
males in previous studies revealing that the mammalian X chromosome is enriched in genes …
[HTML][HTML] Cystic fibrosis and primary ciliary dyskinesia: Similarities and differences
Cystic fibrosis (CF) and Primary ciliary dyskinesia (PCD) are both rare chronic diseases,
inherited disorders associated with multiple complications, namely respiratory …
inherited disorders associated with multiple complications, namely respiratory …
Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis
Y Sha, W Liu, S Li, LV Osadchuk, Y Chen, H Nie… - …, 2023 - thelancet.com
Background Asthenozoospermia is the primary cause of male infertility; however, its genetic
aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the …
aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the …