Towards an understanding of psychedelic-induced neuroplasticity

AE Calder, G Hasler - Neuropsychopharmacology, 2023 - nature.com
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Adverse effects of psychedelics: From anecdotes and misinformation to systematic science

AK Schlag, J Aday, I Salam… - Journal of …, 2022 - journals.sagepub.com
Background: Despite an increasing body of research highlighting their efficacy to treat a
broad range of medical conditions, psychedelic drugs remain a controversial issue among …

[HTML][HTML] Lysergic acid diethylamide–assisted therapy in patients with anxiety with and without a life-threatening illness: A randomized, double-blind, placebo …

F Holze, P Gasser, F Müller, PC Dolder, ME Liechti - Biological Psychiatry, 2023 - Elsevier
Background This study aimed to investigate the efficacy and safety of lysergic acid
diethylamide (LSD)–assisted therapy in patients who experienced anxiety with or without …

[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

The promises and perils of psychedelic pharmacology for psychiatry

TD McClure-Begley, BL Roth - Nature Reviews Drug Discovery, 2022 - nature.com
Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics

CMH De Vos, NL Mason, KPC Kuypers - Frontiers in psychiatry, 2021 - frontiersin.org
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …

Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

F Holze, L Ley, F Müller, AM Becker… - …, 2022 - nature.com
Growing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in
psychiatric research and therapy. However, no modern studies have evaluated differences …

Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

LR Aleksandrova, AG Phillips - Trends in pharmacological sciences, 2021 - cell.com
The emerging therapeutic efficacy of ketamine and classical psychedelics for depression
has inspired tremendous interest in the underlying neurobiological mechanisms. We review …

Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy …

L Ley, F Holze, D Arikci, AM Becker… - …, 2023 - nature.com
Mescaline, lysergic acid diethylamide (LSD), and psilocybin are classic serotonergic
psychedelics. A valid, direct comparison of the effects of these substances is lacking. The …

Blinding and expectancy confounds in psychedelic randomized controlled trials

SD Muthukumaraswamy, A Forsyth… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: There is increasing interest in the potential for psychedelic drugs such as
psilocybin, LSD and ketamine to treat several mental health disorders, with a growing …