Myopia is one of the leading ocular disorders causing visual impairment worldwide, with the
prevalence increasing rapidly. It's a significant global public health concern in 21st century …

Myopia is the most common eye condition leading to visual impairment and is greatly
influenced by genetics. Over the last two decades, more than 400 associated gene loci have …

Co-and post-translational hydroxylation of proline residues is critical for the stability of the
triple helical collagen structure. In this review, we summarise the biology of collagen prolyl 4 …

Collagens are the most abundant proteins in the extracellular matrix. They provide a
framework to build organs and tissues and give structural support to make them resistant to …

Importance High myopia (HM) is one of the leading causes of visual impairment worldwide.
Genetic factors are known to play an important role in the development of HM. Objective To …

Myopia is the most common cause of visual impairment worldwide. Genetic and
environmental factors contribute to the development of myopia. Studies on the molecular …

The axial length of the eye is critical for normal visual function by enabling light to precisely
focus on the retina. The mean axial length of the adult human eye is 23.5 mm, but the …

The etiology of the highly myopic condition has been unclear for decades. We investigated
the genetic contributions to early-onset high myopia (EOHM), which is defined as having a …

Prolyl‐4‐hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …

Past 25y have witnessed an exponential increase in knowledge and understanding of
ocular diseases and their respective genetic underpinnings. As a result, scientists have …