Over the past decade, it was found that relatively simple sphingolipids, such as ceramide,
sphingosine, sphingosine-1-phosphate, and glucosylceramide play important roles in …

Classically, the loss of vulnerable neuronal populations in neurodegenerative diseases was
considered to be the consequence of cell autonomous degeneration of neurons. However …

Background Increasing evidence suggests that patients with Parkinson's disease (PD)
present with peripheral autonomic dysfunction (AutD) that even precedes motor deficits …

The appearance of alpha-synuclein-positive inclusion bodies (Lewy bodies) and the loss of
catecholaminergic neurons are the primary pathological hallmarks of Parkinson's disease …

Parkinson's disease (PD) is the second most common neurodegenerative disease, disabling
millions worldwide. Despite the imperative PD poses, at present, there is no cure or means …

The presynaptic protein α-synuclein (αSyn) has been suggested to be involved in the
pathogenesis of Parkinson's disease (PD). In PD, the amygdala is prone to develop …

Parkinson's disease (PD) is diagnosed by its cardinal motor symptoms that are associated
with the loss of dopamine neurons in the substantia nigra pars compacta (SNc). However …

Parkinson's disease (PD) is a complex neurological condition caused due to inheritance,
environment, and behavior among various other parameters. The onset, diagnosis, course …

To adapt to the sustained demands of chronic stress, discrete brain circuits undergo
structural and functional changes often resulting in anxiety disorders. In some individuals …

No disease-modifying therapy is currently available for Parkinson's disease (PD), the
second most common neurodegenerative disease. The long nonmotor prodromal phase of …