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Mechanisms of mRNA surveillance in eukaryotes
P Hilleren, R Parker - Annual review of genetics, 1999 - annualreviews.org
▪ Abstract A conserved mRNA degradation system, referred to as mRNA surveillance, exists
in eukaryotic cells to degrade aberrant mRNAs. A defining aspect of aberrant transcripts is …
in eukaryotic cells to degrade aberrant mRNAs. A defining aspect of aberrant transcripts is …
Posttranscriptional control of gene expression in yeast
JEG McCarthy - Microbiology and Molecular Biology Reviews, 1998 - journals.asm.org
Studies of the budding yeast Saccharomyces cerevisiae have greatly advanced our
understanding of the posttranscriptional steps of eukaryotic gene expression. Given the wide …
understanding of the posttranscriptional steps of eukaryotic gene expression. Given the wide …
[PDF][PDF] Analysis of codon usage
JF Peden - 2000 - Citeseer
The genetic code uses 64 codons to represent the 20 standard amino acids and the
translation termination signal. Each codon is recognised by a subset of a cell's transfer …
translation termination signal. Each codon is recognised by a subset of a cell's transfer …
Complete Genome Sequence of the Prototype Lactic Acid Bacterium Lactococcus lactis subsp. cremoris MG1363
U Wegmann, M O'Connell-Motherway… - Journal of …, 2007 - journals.asm.org
Lactococcus lactis is of great importance for the nutrition of hundreds of millions of people
worldwide. This paper describes the genome sequence of Lactococcus lactis subsp …
worldwide. This paper describes the genome sequence of Lactococcus lactis subsp …
Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system.
The translation machinery recognizes codons that enter the ribosomal A site with
remarkable accuracy to ensure that polypeptide synthesis proceeds with a minimum of …
remarkable accuracy to ensure that polypeptide synthesis proceeds with a minimum of …
The efficiency of translation termination is determined by a synergistic interplay between upstream and downstream sequences insaccharomyces cerevisiae
B Bonetti, L Fu, J Moon, DM Bedwell - Journal of molecular biology, 1995 - Elsevier
In a recent study we found that the efficiency of translation termination could be decreased
several hundred fold by altering the local sequence context surrounding stop codons in the …
several hundred fold by altering the local sequence context surrounding stop codons in the …
Translational termination efficiency in mammals is influenced by the base following the stop codon.
The base following stop codons in mammalian genes is strongly biased, suggesting that it
might be important for the termination event. This proposal has been tested experimentally …
might be important for the termination event. This proposal has been tested experimentally …
The identity of the base following the stop codon determines the efficiency of in vivo translational termination in Escherichia coli
A statistical analysis of> 2000 Escherichia coli genes suggested that the base following the
translational stop codon might be an important feature of the signal for termination. The …
translational stop codon might be an important feature of the signal for termination. The …
Engineered transfer RNAs for suppression of premature termination codons
Premature termination codons (PTCs) are responsible for 10–15% of all inherited disease.
PTC suppression during translation offers a promising approach to treat a variety of genetic …
PTC suppression during translation offers a promising approach to treat a variety of genetic …
[PDF][PDF] An overview of the parameters for recombinant protein expression in Escherichia coli
Escherichia coli, is one of the most widely preferred organism for the production of
recombinant protein. Most of the FDA approved therapeutic proteins are produced in E. coli …
recombinant protein. Most of the FDA approved therapeutic proteins are produced in E. coli …